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Nina Kostina, PhD

Postdoctoral Researcher

kostina [at] dwi.rwth-aachen.de

Nina Kostina is a postdoc at DWI-Leibniz Institute for Interactive Materials. Her research interests lye in the development of new concepts for fully synthetic cell membrane mimics with biomimetic thickness, improved stability while maintaining important functionalities such as flexibility, lateral mobility, asymmetry in leaflets and 2D-segregation. 

 

Publications

Enhanced concanavalin A binding to preorganized mannose nanoarrays in glycodendrimersomes revealed multivalent interactions

Kostina, N. Yu.*; Söder, D.*; Haraszti, T.; Xiao, Q.; Rahimi, K.; Patridge, B. E.; Klein, M. L.; Percec, V.; Rodriguez-Emmenegger, C.

Angewandte Chemie, DOI:10.1002/anie.202100400 (2021)

* equal contributions

Unraveling Topology-Induced Shape Transformations in Dendrimersomes

Kostina, N. Yu.*; Wagner, A. M.*; Haraszti, T.; Rahimi, K.; Xiao,Q.; Klein, M. L.; Percec, V.; Rodriguez-Emmenegger, C.

Soft Matter (Invited paper in themed collection: Remodelling of Biomembranes, Highlighted in front cover), 17, 254-267 (2021)

* equal contributions

Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms

Li, S.; Xia, B.; Javed, B.; Hasley, W. D.; Melendez-Davila, A.; Liu, M.; Kerzner, M.; Agarwal, S.; Xiao, Q.; Torre, P.; Bermudez, J. G.; Rahimi, K.; Kostina, N. Yu.; Moeller, M.; Rodriguez-Emmenegger, C.; Klein, M. L.; Percec, V.; Good, M. C.

ACS Nano, DOI: 10.1021/acsnano.0c02912 (2020)

Nanovesicles Displaying Functional Linear and Branched Oligomannose Self-Assembled from Sequence-Defined Janus Glycodendrimers

Xiao, Q.; Delbianco, M.; Sherman, S. E.; Reveron Perez, A. M.; Bharate, P.; Pardo-Vargas, A.;  Rodriguez-Emmenegger, C.; Kostina, N. Yu.; Rahimi, K.; Söder, D.; Möller, M.; Klein, M. L.; Seeberger, P. H.; Percec, V.

PNAS, 117 (22), 11931-11939 (2020)

Membrane-Mimetic Dendrimersomes Engulf Living Bacteria via Endocytosis

Kostina, N. Yu.; Rahimi, K.; Xiao, Q.; Haraszti, T.; Dedisch, S.; Spatz, J.; Schwaneberg, U.; Klein, M. L.; Percec, V.; Moeller, M.; Rodriguez-Emmenegger, C.
Nano Letters, (Just Accepted) (2019) https://pubs.acs.org/doi/10.1021/acs.nanolett.9b02349

Encapsulation of Hydrophobic Components in Dendrimersomes and Decoration of Their Surface with Proteins and Nucleic Acids

Torre, P.; Xiao, Q.; Buzzacchera, I.; Sherman, S. E.;  Rahimi, K.; Kostina, N. Yu.; Rodriguez-Emmenegger, C.; Möller, M.; Wilson, C. J.; Klein, M. L.; Good, M. C.; Percec, V.
Proceedings of the National Academy of Sciences, (Just Accepted) (2019) doi.org/10.1073/pnas.1904868116

Encoding Biological Recognition in a Bicomponent Cell-Membrane Mimic

Rodriguez-Emmenegger, C.; Xiao, Q.; Kostina, N. Yu.; Sherman, S. E.; Rahimi, K.; Partridge, B. E.; Li, S.; Sahoo, D.; Perez, A. M. R.; Buzzacchera, I.; Han, H.; Kerzner, M.; Malhotra, I.; Möller, M.; Wilson, C. J.; Good, M. C.; Goulian, M.; Baumgart, T.; Klein, M. L.; Percec, V.
Proceedings of the National Academy of Sciences, 116 (8), 5376-5382 (2019)

Design–Functionality Relationships for Adhesion/Growth-Regulatory Galectins

Ludwig, A. K.; Michalak, M.; Xiao, Q.; Gilles, U.; Medrano, F. J.; Ma, H.; FitzGerald, F. G.; Hasley, W. D.; Melendez-Davila, A.; Liu, M.; Rahimi, K.; Kostina, N. Yu.; Rodriguez-Emmenegger, C.; Möller, M.; Lindner, I.; Kaltner, H.; Cudic, M.; Reusch, D.; Kopitz, J.; Romero, A.; Oscarson, S.; Klein, M. L.; Gabius, H. J.; Percec, V.

Proceedings of the National Academy of Sciences, 116 (8), 2837-2842 (2019)

Antifouling Microparticles to Scavenge Lipopolysaccharide from Human Blood Plasma

Vorobii, M.; Kostina, N. Yu.; Rahimi, K.; Grama, S.; Söder, S.; Pop-Georgievski, O.; Sturcova, A.; Horak, D.; Grottke, O.; Singh, S.; Rodriguez-Emmenegger, C.

Biomacromolecules, 20 (2), 959-968 (2019)

Zwitterionic Functionalizable Scaffolds with Gyroid Pore Architecture for Tissue Engineering

Kostina, N. Yu.; Blanquer, S.; Pop‐Georgievski, O.; Rahimi, K.; Dittrich, B.; Höcherl, A.; Michálek, J.; Grijpma, D. W.; Rodriguez‐Emmenegger, C.

Macromolecular Bioscience, 19, 1800403 (2019)

Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Ddendrimersomes

Buzzacchera, I.; Xiao, Q.; Han, H.; Rahimi, K.;Li, S.; Kostina, N. Yu.; Toebes, B. J.; Wilner, S.E.; Möller, M.; Rodriguez-Emmenegger, C.; Baumgart, T.; Wilson, D.A.; Wilson, C. J.; Klein, M.L.; Percec, V. Biomacromolecules, 20 (2), 712-727 (2018)

 

Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings

Buzzacchera, I.; Vorobii, M.; Kostina, N. Y.; de Los Santos Pereira, A.; Riedel, T.; Bruns, M.; Ogieglo, W.; Moller, M.; Wilson, C. J.; Rodriguez-Emmenegger, C.

Biomacromolecules, 18 (6), 1983-1992 (2017)

Grafting of Functional Methacrylate Polymer Brushes by Photoinduced SET-LRP

Vorobii, M.; Pop-Georgievski, O.; de los Santos Pereira, A.; Kostina, N. Yu.; Jezorek, R.; Sedlakova, Z.; Percec, V.; Rodriguez-Emmenegger, C.

Polymer Chemistry, 7 (45), 6934-6945 (2016)

Non-Fouling Biodegradable Poly(ε-caprolactone) Nanofibers for Tissue Engineering

Kostina, N. Yu.; Pop-Georgievski, O.; Bachmann, M.; Neykova,N.; Bruns, M.; Michalek, J.; Bastmeyer, M.; Rodriguez-Emmenegger, C. 

Macromolecular Bioscience, 16 (1), 83-94 (2016)

Designing Molecular Printboards: A Photolithographic Platform for Recodable Surfaces

Abt, D.; Schmidt, B. V. K. J.; Pop-Georgievski, O.; Quick, A. S.; Danilov, D.; Kostina, N. Yu.; Bruns, M.; Wenzel, W.; Wegener, M.; Rodriguez-Emmenegger, C.; Barner-Kowollik, C.

Chemistry – A European Journal, 21 (38), 13186-13190

 

Photo-Triggered Functionalization of Hhierachically Structured Brushes

 

de los Santos Pereira, A.; Kostina, N. Yu.; Bruns, M.; Rodriguez-Emmenegger, C.; Barner-Kowollik, C.

Langmuir, 31 (21), 5899-5907 (2015)

Synthesis of Non‐Fouling Poly[N‐(2‐Hydroxypropyl)methacrylamide] Brushes by Photoinduced SET-LRP

Vorobii, M.; de los Santos Pereira, A.; Pop‐Georgievski, O.; Kostina, N. Yu.; Rodriguez‐Emmenegger, C.; Percec, V.

Polymer Chemistry, 6 (23), 4210-4220. (Highlighted in the inner cover paper) (2015)

Polymer Brushes Interfacing Blood as a Route Toward High Performance Blood Contacting Devices

Surman, F.; Riedel, T.; Bruns, M.; Kostina, N. Yu.; Sedláková, Z.; Rodriguez-Emmenegger, C.

Macromolecular Biosciences, 15 (5), 636-646 (2015)

Novel Antifouling Self-Healing Poly(carboxybetaine methacrylamide-co-HEMA) Nanocomposite Hydrogels With Superior Mechanical Properties

Kostina, N. Yu.; Sharifi, S.; de los Santos Pereira, A.; Michálek, J.; Grijpma, D. W.; Rodriguez-Emmenegger, C.

Journal of Materials Chemistry B, 1 (41), 5644-5650 (2013)

Non-Fouling Hydrogels of 2-Hydroxyethyl Methacrylate and Zwitterionic Carboxybetaine (meth)acrylamides

Kostina, N. Yu.; Rodriguez-Emmenegger, C.; Houska, M.; Brynda, E.; Michalek, J.

Biomacromolecules, 13 (12), 4164-4170 (2012)

Water-Soluble Polyplexes of modified Chitosan

Kostina, N. Yu.; Gorshkova, M. Yu.; Izumrudov, V. A.

Polymer Science Series A, 53 (10), 947 (2011)